Probiotics Administration Alleviates Cognitive Impairment and Circadian Rhythm Disturbance Induced by Sleep Deprivation

Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In this study, neurobehavioral effects of the Bifidobacterium breve strain CCFM1025 were assessed sleep-deprived mice. improved body weight and food water intake It also alleviated SD-induced behavioural abnormalities (in novel object recognition test), but did not show beneficial on mood- spatial memory-related behaviours. significantly altered microbial composition genome Key metabolites that may regulate function identified, such as isovaleric acid γ-aminobutyric purine serum. Those participate gut–brain communication by acting striatal melatonin system, example to increase levels, regulating expression circadian clock genes those encoding adenosine A2A receptor period regulator 1. Collectively, administration probiotics impairment rhythm disturbance induced SD via modulation its metabolites. These findings help guide treatment insomnia or other disorders dietary strategies.